CircNFIX promotes progression of pituitary adenoma via CCNB1 by sponging miR-34a -5p

Previous studies have shown that CCNB1 affects the invasiveness of pituitary adenomas, and it is great significance to find upstream mechanism regulating CCNB1.In this study, we explored a significantly overexpressed circRNA in invasive adenomas. Based on bioinformatics analysis experiments, determined circNFIX (has-circ_0005660) cell invasion, migration proliferation adenomas by sponging miR-34a-5p through CCNB1. In adenoma tissues, expression was upregulated, while downregulated. The silencing or overexpression inhibited proliferation. Inhibition reversed inhibitory effect progression adenoma. conclusion, CircNFIX migration, Therefore, expected serve as potential target for treatment